Brand  (β version)

PDB ID: 3CWB

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Ligands
Code Name Style Show Link
AZI Azide ion PoSSuM
CDL Cardiolipin PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
HEC Heme C PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
ICX Methyl N-[(5z)-6-({[4-(4-iodobenzyl)phenyl]carbonyl}amino)hex-5-enoyl]glycinate PoSSuM
PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine PoSSuM
UNL Unknown ligand PoSSuM
UQ Coenzyme q10, (2z,6e,10z,14e,18e,22e,26z)-isomer PoSSuM
BOG Octyl beta-D-glucopyranoside PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3CWB   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Chicken Cytochrome BC1 Complex inhibited by an iodinated analogue of the polyketide Crocacin-D
Release Data : 2008-08-12
Compound :
mol_id molecule chains
1 MITOCHONDRIAL UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX CORE PROTEIN I A,N
mol_id molecule chains
2 MITOCHONDRIAL UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX CORE PROTEIN 2 B,O
mol_id molecule chains synonym
3 Cytochrome b C,P Ubiquinol-cytochrome-c reductase complex cytochrome b subunit, Cytochrome b-c1 complex subunit 3, Complex III subunit 3, Complex III subunit III
mol_id molecule chains
4 MITOCHONDRIAL CYTOCHROME C1, HEME PROTEIN D,Q
mol_id molecule chains
5 MITOCHONDRIAL UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR PROTEIN E,R
mol_id molecule chains
6 MITOCHONDRIAL UBIQUINOL-CYTOCHROME C REDUCTASE 14 KDA PROTEIN F,S
mol_id molecule chains
7 MITOCHONDRIAL UBIQUINOL-CYTOCHROME C REDUCTASE UBIQUINONE-BINDING PROTEIN QP-C G,T
mol_id molecule chains
8 MITOCHONDRIAL UBIQUINOL-CYTOCHROME C REDUCTASE 11 KDA PROTEIN, COMPLEX III SUBUNIT VIII H,U
mol_id molecule chains
9 MITOCHONDRIAL UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT, leader sequence I,V
mol_id molecule chains
10 MITOCHONDRIAL UBIQUINOL-CYTOCHROME C REDUCTASE 7.2 KDA PROTEIN J,W
Source :
mol_id organism_scientific organism_common
1 Gallus gallus  (taxid:9031) Chicken
mol_id organism_scientific organism_common
2 Gallus gallus  (taxid:9031) Chicken
mol_id organism_scientific organism_common
3 Gallus gallus  (taxid:9031) Chicken
mol_id organism_scientific organism_common
4 Gallus gallus  (taxid:9031) Chicken
mol_id organism_scientific organism_common
5 Gallus gallus  (taxid:9031) Chicken
mol_id organism_scientific organism_common
6 Gallus gallus  (taxid:9031) Chicken
mol_id organism_scientific organism_common
7 Gallus gallus  (taxid:9031) Chicken
mol_id organism_scientific organism_common
8 Gallus gallus  (taxid:9031) Chicken
mol_id organism_scientific organism_common
9 Gallus gallus  (taxid:9031) Chicken
mol_id organism_scientific organism_common
10 Gallus gallus  (taxid:9031) Chicken
Authors : Huang, L., Cromartie, T., Viner, R., Crowley, P.J., Berry, E.A.
Keywords : Crocacin D, inhibitor design, structure-activity relationship, polyketide, fungicide, CYTOCHROME BC1, MEMBRANE PROTEIN, HEME PROTEIN, RIESKE IRON SULFUR PROTEIN, CYTOCHROME B, CYTOCHROME C1, COMPLEX III, MITOCHONDRIAL PROCESSING PROTEA UBIQUINONE, OXIDOREDUCTASE, REDOX ENZYME, RESPIRATORY CHAIN, Electron transport, Heme, Inner membrane, Iron, Membrane, Metal-binding, Mitochondrion, Transmembrane, Transport
Exp. method : X-RAY DIFFRACTION ( 3.51 Å )
Citation :

The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D.

Crowley, P.J.,Berry, E.A.,Cromartie, T.  et al.
(2008)  Bioorg.Med.Chem.  16 : 10345 - 10355

PubMed: 18996700
DOI: 10.1016/j.bmc.2008.10.030

Electron transfer by domain movement in cytochrome bc1.

Zhang, Z.,Huang, L.,Shulmeister, V.M.  et al.
(1998)  Nature  392 : 677 - 684

PubMed: 9565029
DOI: 10.1038/33612

Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern.

Huang, L.S.,Cobessi, D.,Tung, E.Y.  et al.
(2005)  J.Mol.Biol.  351 : 573 - 597

PubMed: 16024040
DOI: 10.1016/j.jmb.2005.05.053

Reaction

Chain : C, P
UniProt : P18946 (CYB_CHICK)
Reaction : -
Chain : I, V
UniProt : Q5ZLR5 (UCRI_CHICK)
Reaction: EC: Evidence:
Physiological Direction:
a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out) 7.1.1.8 UniProtKB:P08067
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