Brand  (β version)

PDB ID: 3CVW

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
FO1 1-deoxy-1-(8-hydroxy-2,4-dioxo-3,4-dihydropyrimido[4,5-B]quinolin-10(2h)-yl)-D-ribitol PoSSuM
Non-standard Residues
Code Name Show
5PY 1-(2'-deoxy-5'-O-phosphono-beta-D-erythro-pentofuranosyl)-5-methylpyrimidin-2(1h)-one
64T 5-hydroxy-thymidine-5'-monophosphate
Glycosylation
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Modification
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Structure summary

Code : 3CVW   PDBj   RCSB PDB   PDBe
Header : Lyase/DNA
Title : Drosophila melanogaster (6-4) photolyase H365N mutant bound to ds DNA with a T-T (6-4) photolesion and cofactor F0
Release Data : 2009-10-13
Compound :
mol_id molecule chains
1 DNA (5'-D(*DAP*DCP*DAP*DGP*DCP*DGP*DGP*(64T)P*(5PY)P*DGP*DCP*DAP*DGP*DGP*DT)-3') C
other_details: DNA with (6-4) photolesion
mol_id molecule chains
2 DNA (5'-D(*DTP*DAP*DCP*DCP*DTP*DGP*DCP*DAP*DAP*DCP*DCP*DGP*DCP*DTP*DG)-3') D
mol_id molecule chains
3 RE11660p A
mutation: H365N
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific
2
synthetic: yes
mol_id organism_scientific expression_system
3 Drosophila melanogaster  (taxid:7227) Escherichia coli  (taxid:562)
gene: phr64-520
expression_system_strain: Rosetta-gami pLysS (DE-3)
expression_system_vector_type: PLASMID
expression_system_plasmid: derived from pDEST007
Authors : Maul, M.J., Barends, T.R.M., Glas, A.F., Cryle, M.J., Schlichting, I., Carell, T.
Keywords : DNA repair, Lyase-DNA COMPLEX
Exp. method : X-RAY DIFFRACTION ( 3.20 Å )
Citation :

Structure and mechanism of a cofactor f0 accelerated (6-4) photolyase from the fruit fly

Maul, M.J.,Barends, T.,Glas, A.F.  et al.
To be Published 

Reaction

Chain : A
UniProt : Q8SXK5 (Q8SXK5_DROME)
Reaction : -
Cofactor: Evidence: Note:
FAD ECO:0000256 | PIRSR:PIRSR602081-1
Binds 1 FAD per subunit.