Brand  (β version)

PDB ID: 3CSJ

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Ligands
Code Name Style Show Link
CBL Chlorambucil PoSSuM
CL Chloride ion PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3CSJ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human glutathione S-transferase p1-1 in complex with chlorambucil
Release Data : 2008-07-01
Compound :
mol_id molecule chains synonym
1 Glutathione S-transferase P A,B GST class-pi, GSTP1-1
ec: 2.5.1.18
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens Human Escherichia coli
gene: GSTP1, FAEES3, GST3
expression_system_strain: TOP10
expression_system_vector_type: plasmid
expression_system_plasmid: PGST-1
Authors : Parker, L.J.
Keywords : TRANSFERASE, GLUTATHIONE, DETOXIFICATION, CHLORAMBUCIL, Polymorphism
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants.

Parker, L.J.,Ciccone, S.,Italiano, L.C.  et al.
(2008)  J.Mol.Biol.  380 : 131 - 144

PubMed: 18511072
DOI: 10.1016/j.jmb.2008.04.066

Reaction

Chain : A, B
UniProt : P09211 (GSTP1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
glutathione + RX = a halide anion + an S-substituted glutathione + H(+) 2.5.1.18 PubMed:1540159, PubMed:1567427, PubMed:8433974
left-to-right ECO:0000305
glutathione + prostaglandin J2 = prostaglandin J2-S-(R)- glutathione - PubMed:9084911
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glutathione + prostaglandin J2 = prostaglandin J2-S-(S)- glutathione - PubMed:9084911
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glutathione + prostaglandin A2 = prostaglandin A2-S-(S)- glutathione - PubMed:9084911
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11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)- eicosatrienoate - PubMed:21046276
left-to-right