PDB ID: 3CAV
Hetero Atom Contents
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Data format:
Color scheme of protein:
Code | Name | Style | Show | Link | |
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NAP | Nadp nicotinamide-adenine-dinucleotide phosphate | PoSSuM | |||
CI2 | (5beta)-pregnane-3,20-dione | PoSSuM | |||
BME | Beta-mercaptoethanol | PoSSuM | |||
EDO | 1,2-ethanediol | PoSSuM |
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Download interaction data: 3CAV
Structure summary
Code : | 3CAV PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE | ||||||||||||
Title : | Crystal structure of 5beta-reductase (AKR1D1) in complex with NADP+ and 5beta-pregnan-3,20-dione | ||||||||||||
Release Data : | 2008-07-29 | ||||||||||||
Compound : |
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Authors : | Faucher, F., Cantin, L., Breton, R. | ||||||||||||
Keywords : | 5b-reductase, 5beta-reductase, 5b-red, AKR1D1, AKR, aldo-keto reductase, NADP, androstenedione. NADPH, Bile acid catabolism, Cytoplasm, Disease mutation, Lipid metabolism, Oxidoreductase, Steroid metabolism | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.900 Å ) | ||||||||||||
Citation : |
The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism.
Faucher, F.,Cantin, L.,Luu-The, V.
et al.
PubMed: 18624455 |
Reaction
Chain : | A, B | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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UniProt : | P51857 (AK1D1_HUMAN) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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