Brand  (β version)

PDB ID: 3C1X

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Ligands
Code Name Style Show Link
CKK N-{[4-({5-[(4-aminopiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}oxy)-3-fluorophenyl]carbamoyl}-2-(4-fluorophenyl)acetamide PoSSuM
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Structure summary

Code : 3C1X   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a Pyrrolotriazine based inhibitor
Release Data : 2008-03-18
Compound :
mol_id molecule chains synonym
1 Hepatocyte growth factor receptor A MET PROTO-ONCOGENE TYROSINE KINASE, C-MET, HGF RECEPTOR, HGF/SF RECEPTOR, SF receptor, Scatter factor receptor
ec: 2.7.10.1
fragment: tyrosine kinase domain, UNP residues 1049-1360
mutation: Y1194F, Y1234F, Y1235D, V1272L
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: MET
expression_system_common: Fall armyworm
expression_system_cell_line: SPODOPTERA FRUGIPERDA 9 (Sf9)
expression_system_vector_type: BACULOVIRUS
expression_system_vector: pAcHLT-A
Authors : Sack, J.
Keywords : RECEPTOR TYROSINE KINASE, SIGNAL TRANSDUCTION, GRB2, SHC, ATP-binding, Glycoprotein, Membrane, Nucleotide-binding, Phosphoprotein, Proto-oncogene, Transferase, Transmembrane, Tyrosine-protein kinase
Exp. method : X-RAY DIFFRACTION ( 2.17 Å )
Citation :

Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase.

Schroeder, G.M.,Chen, X.T.,Williams, D.K.  et al.
(2008)  Bioorg.Med.Chem.Lett.  18 : 1945 - 1951

PubMed: 18289854
DOI: 10.1016/j.bmcl.2008.01.121

Reaction

Chain : A
UniProt : P08581 (MET_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028
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