Brand  (β version)

PDB ID: 3BMY

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CXZ 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 3BMY   PDBj   RCSB PDB   PDBe
Header : CHAPERONE
Title : Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90
Release Data : 2008-07-08
Compound :
mol_id molecule chains synonym
1 Heat shock protein HSP 90-alpha A HSP 86, Renal carcinoma antigen NY-REN-38
fragment: N-terminal domain, UNP residues 10-236
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: HSP90AA1, HSP90A, HSPC1, HSPCA
expression_system_strain: BL21DE3
expression_system_vector_type: plasmid
expression_system_plasmid: pET29A
Authors : Gopalsamy, A., Shi, M., Vogan, E.M., Golas, J., Jacob, J., Johnson, J., Lee, F., Nilakantan, R., Peterson, R., Svenson, K., Tam, M.S., Wen, Y., Chopra, R., Ellingboe, J., Arndt, K., Boschelli, F.
Keywords : Chaperone, ATP binding domain, Alternative splicing, ATP-binding, Cytoplasm, Nucleotide-binding, Phosphoprotein, Stress response
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.

Gopalsamy, A.,Shi, M.,Golas, J.  et al.
(2008)  J.Med.Chem.  51 : 373 - 375

PubMed: 18197612
DOI: 10.1021/jm701385c

Reaction

Chain : A
UniProt : P07900 (HS90A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + H2O = ADP + H(+) + phosphate 3.6.4.10 PubMed:12526792
-