Brand  (β version)

PDB ID: 3BLR

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Ligands
Code Name Style Show Link
CPB 2-(2-chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-4h-benzopyran-4-one PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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TPO Phosphothreonine
Glycosylation
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Structure summary

Code : 3BLR   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol
Release Data : 2008-07-01
Compound :
mol_id molecule chains synonym
1 Cell division protein kinase 9 A Cyclin-dependent kinase 9, Serine/threonine-protein kinase PITALRE, C-2K, Cell division cycle 2-like protein kinase 4
ec: 2.7.11.22, 2.7.11.23
fragment: UNP residues 2-330
mol_id molecule chains synonym
2 Cyclin-T1 B CycT1, Cyclin-T
fragment: UNP residues 2-259
mutation: Q77R, E96G, F241L
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CDK9
expression_system_common: Fall armyworm
expression_system_strain: SF9
expression_system_vector_type: Baculo virus
expression_system_plasmid: pVL1392
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CCNT1
expression_system_common: Fall armyworm
expression_system_strain: SF9
expression_system_vector_type: Baculo virus
expression_system_plasmid: pVL1392
Authors : Baumli, S., Lolli, G., Lowe, E.D., Johnson, L.N.
Keywords : transcriptional CDK-cyclin complex, phosphorylated, Flavopiridol, Alternative splicing, ATP-binding, Kinase, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Serine/threonine-protein kinase, Transcription regulation, Transferase, Acetylation, Cell cycle, Cell division, Coiled coil, Host-virus interaction, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.800 Å )
Citation :

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

Baumli, S.,Lolli, G.,Lowe, E.D.  et al.
(2008)  Embo J.  27 : 1907 - 1918

PubMed: 18566585
DOI: 10.1038/emboj.2008.121

Reaction

Chain : A
UniProt : P50750 (CDK9_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:12037670, PubMed:20980437, PubMed:29335245
left-to-right
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:12037670, PubMed:20980437
left-to-right PubMed:12037670, PubMed:20980437
[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho- [DNA-directed RNA polymerase] 2.7.11.23 PubMed:21127351, PubMed:28426094
left-to-right
Chain : B
UniProt : O60563 (CCNT1_HUMAN)
Reaction : -