Brand  (β version)

PDB ID: 3BKI

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Ligands
Code Name Style Show Link
FQX [1,2,5]oxadiazolo[3,4-G]quinoxaline-6,7(5h,8h)-dione 1-oxide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3BKI   PDBj   RCSB PDB   PDBe
Header : TRANSPORT PROTEIN
Title : Crystal Structure of the GluR2 ligand binding core (S1S2J) in complex with FQX at 1.87 Angstroms
Release Data : 2008-09-16
Compound :
mol_id molecule chains synonym
1 Glutamate receptor 2 P,B,C,D GluR-2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, AMPA-selective glutamate receptor 2
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Rat Escherichia coli  (taxid:562)
gene: Gria2, Glur2
Authors : Cruz, L., Estebanez-Perpina, E., Pfaff, S., Borngraeber, S., Bao, N., Fletterick, R., England, P.
Keywords : AMPA receptor, ANQX, quinoxaline-2, 3-diones, Alternative splicing, Cell junction, Endoplasmic reticulum, Glycoprotein, Ion transport, Ionic channel, Lipoprotein, Membrane, Palmitate, Phosphoprotein, Postsynaptic cell membrane, RNA editing, Synapse, Transmembrane, Transport, TRANSPORT PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.87 Å )
Citation :

6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor.

Cruz, L.A.,Estebanez-Perpina, E.,Pfaff, S.  et al.
(2008)  J.Med.Chem.  51 : 5856 - 5860

PubMed: 18754610
DOI: 10.1021/jm701517b

Reaction

Chain : P, B, C, D
UniProt : P19491 (GRIA2_RAT)
Reaction : -