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Ligands
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01K [(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3r,20r)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate
BR Bromide ion
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Code : 3BIY   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of p300 histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA
Release Data : 2008-02-12
Compound :
mol_id molecule chains synonym
1 Histone acetyltransferase p300 A E1A-associated protein p300
ec: 2.3.1.48
fragment: acetyltransferase domain
mutation: K1637R, M1652G
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: EP300, P300
expression_system_strain: BL21(DE3)-CodonPlus
expression_system_vector_type: Plasmid
expression_system_plasmid: pTYB2
Authors : Liu, X., Wang, L., Zhao, K., Thompson, P.R., Hwang, Y., Marmorstein, R., Cole, P.A.
Keywords : p300 HAT, Bisubstrate inhibitor, protein-inhibitor complex, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

Liu, X.,Wang, L.,Zhao, K.  et al.
(2008)  Nature  451 : 846 - 850

PubMed: 18273021
DOI: 10.1038/nature06546

Chain : A
UniProt : Q09472 (EP300_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein] 2.3.1.48 PubMed:15448695, PubMed:17761950, PubMed:23415232, PubMed:23934153, PubMed:24120661, PubMed:30197302, PubMed:32561715, PubMed:8945521
left-to-right PubMed:15448695, PubMed:30197302, PubMed:32561715
(2E)-butenoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)- (2E)-butenoyl-L-lysyl-[protein] - PubMed:25818647
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butanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-butanoyl- L-lysyl-[protein] - UniProtKB:B2RWS6
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L-lysyl-[protein] + propanoyl-CoA = CoA + H(+) + N(6)- propanoyl-L-lysyl-[protein] - PubMed:17267393
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2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] - PubMed:29775581
left-to-right
L-lysyl-[protein] + lactoyl-CoA = CoA + H(+) + N(6)-lactoyl-L- lysyl-[protein] - PubMed:31645732
left-to-right