PDB ID: 3BCJ
Hetero Atom Contents
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Color scheme of protein:
Code | Name | Style | Show | Link | |
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CIT | Citric acid | PoSSuM | |||
FIS | (2s,4r)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione | PoSSuM | |||
NAP | Nadp nicotinamide-adenine-dinucleotide phosphate | PoSSuM |
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Download interaction data: 3BCJ
Structure summary
Code : | 3BCJ PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE | ||||||||||||
Title : | Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A | ||||||||||||
Release Data : | 2008-04-08 | ||||||||||||
Compound : |
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Authors : | Zhao, H.T., El-Kabbani, O. | ||||||||||||
Keywords : | Aldo-Keto Reductases, Diabetes, Drug Design, Polyl Pathway, Acetylation, Cataract, Cytoplasm, NADP, Oxidoreductase, Polymorphism | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 0.78 Å ) | ||||||||||||
Citation : |
Unusual Binding Mode of the 2S4R Stereoisomer of the Potent Aldose Reductase Cyclic Imide Inhibitor Fidarestat (2S4S) in the 15 K Crystal Structure of the Ternary Complex Refined at 0.78 A Resolution: Implications for the Inhibition Mechanism
Zhao, H.T.,Hazemann, I.,Mitschler, A.
et al.
PubMed: 18284183 |
Reaction
Chain : | A | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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UniProt : | P15121 (ALDR_HUMAN) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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