Het-PDB Navi2 (PDB: 3BBT)

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Ligands
Code	Name		Style	Show	Link
FMM	N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine				PoSSuM

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Download interaction data: 3BBT

Code :

3BBT PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

crystal structure of the ErbB4 kinase in complex with lapatinib

Release Data :

2008-02-12

Compound :

mol_id	molecule	chains	synonym
1	Receptor tyrosine-protein kinase erbB-4	B,D	p180erbB4, Tyrosine kinase-type cell surface receptor HER4
	ec: 2.7.10.1

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: ERBB4, HER4 expression_system_common: Fall armyworm expression_system_strain: Sf9 expression_system_vector_type: baculovirus expression_system_plasmid: pFastBac

Authors :

Qiu, C.

Keywords :

inactive kinase conformation, ATP-binding, Glycoprotein, Membrane, Nucleotide-binding, Phosphoprotein, Receptor, Transferase, Transmembrane, Tyrosine-protein kinase

Exp. method :

X-RAY DIFFRACTION ( 2.800 Å )

Citation :

Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase.

Qiu, C.,Tarrant, M.K.,Choi, S.H. et al.
(2008) Structure 16 : 460 - 467

PubMed: 18334220
DOI: 10.1016/j.str.2007.12.016

Chain :

B, D

UniProt :

Q15303 (ERBB4_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:18287036, PubMed:18334220, PubMed:19098003, PubMed:8617750
	-

PDB ID: 3BBT

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Structure summary

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