Brand  (β version)

PDB ID: 3BBB

Hetero Atom Contents

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
DA 2'-deoxyadenosine-5'-monophosphate PoSSuM
DG 2'-deoxyguanosine-5'-monophosphate PoSSuM

Structure summary

Code : 3BBB
Header : TRANSFERASE
Title : Crystal structure of the NM23-H2 transcription factor complex with dinucleotide D(AG)
Release Data : 2008-09-23
Compound :
mol_id molecule chains synonym
1 Nucleoside diphosphate kinase B A,B,C,D,E,F NDK B, NDP kinase B, nm23-H2, C-myc purine-binding transcription factor PUF
ec: 2.7.4.6
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: NME2, NM23B
expression_system_strain: BL21(DE3)pLysS
expression_system_plasmid: plasmid
Authors : Weichsel, A., Montfort, W.R.
Keywords : transcription factor, cancer, nm23 gen, hexamer, Activator, Anti-oncogene, ATP-binding, Cell cycle, DNA-binding, Kinase, Magnesium, Metal-binding, Nucleotide metabolism, Nucleotide-binding, Nucleus, Phosphorylation, Transcription regulation, Transferase
Exp. method : X-RAY DIFFRACTION ( 1.30 Å )
Citation :

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1.

Dexheimer, T.S.,Carey, S.S.,Zuohe, S.  et al.
(2009)  Mol.Cancer Ther.  8 : 1363 - 1377

PubMed: 19435876
DOI: 10.1158/1535-7163.MCT-08-1093

X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2 A resolution.

Morera, S.,Lacombe, M.L.,Xu, Y.  et al.
(1995)  Structure  3 : 1307 - 1314

PubMed: 8747457
DOI: 10.1016/S0969-2126(01)00268-4

Reaction

Chain : A, B, C, D, E, F
UniProt : P22392 (NDKB_HUMAN)
Reaction : ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
ATP + protein L-histidine = ADP + protein N- phospho-L-histidine.