Het-PDB Navi2 (PDB: 3B8Q)

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Ligands
Code	Name		Style	Show	Link
900	N-(4-chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide				PoSSuM

Non-standard Residues
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Download interaction data: 3B8Q

Code :

3B8Q PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of the VEGFR2 kinase domain in complex with a naphthamide inhibitor

Release Data :

2008-04-01

Compound :

mol_id	molecule	chains	synonym
1	Vascular endothelial growth factor receptor 2	A,B	VEGFR-2, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, CD309 antigen
	ec: 2.7.10.1 fragment: kinase domain; UNP residues 815-939, 990-1171 mutation: C817A, V916T, E990V

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Trichoplusia ni (taxid:7111)
	gene: KDR, FLK1 expression_system_common: Cabbage looper expression_system_vector_type: baculovirus

Authors :

Whittington, D.A., Long, A.M., Gu, Y., Zhao, H.

Keywords :

receptor tyrosine kinase, angiogenesis, ATP-binding, Developmental protein, Differentiation, Glycoprotein, Host-virus interaction, Immunoglobulin domain, Membrane, Nucleotide-binding, Phosphorylation, Polymorphism, Transferase, Transmembrane, Tyrosine-protein kinase

Exp. method :

X-RAY DIFFRACTION ( 2.75 Å )

Citation :

Naphthamides as Novel and Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Design, Synthesis and Evaluation

Harmange, J.C.,Weiss, M.M.,Germain, J. et al.
(2008) J.Med.Chem. 51 : 1649 - 1667

PubMed: 18324761
DOI: 10.1021/jm701097z

Chain :

A, B

UniProt :

P35968 (VGFR2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:10037737, PubMed:10102632
	-	PROSITE-ProRule:PRU10028, PubMed:10037737, PubMed:10102632

PDB ID: 3B8Q

Hetero Atom Contents

Structure summary

Reaction