Brand  (β version)

PDB ID: 3B7J

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Ligands
Code Name Style Show Link
BEN Benzamidine PoSSuM
CL Chloride ion PoSSuM
JUG 5-hydroxynaphthalene-1,4-dione PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3B7J   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase(FabZ) from Helicobacter pylori complexed with juglone
Release Data : 2008-09-02
Compound :
mol_id molecule chains synonym
1 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase A,B,C,D,E,F (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase, FabZ
ec: 4.2.1.-
Source :
mol_id organism_scientific organism_common expression_system
1 Helicobacter pylori  (taxid:210) Campylobacter pylori Escherichia coli  (taxid:562)
strain: SS1
gene: fabZ
expression_system_strain: M15
expression_system_vector_type: PLASMID
expression_system_plasmid: pQE30
Authors : Zhang, L., Kong, Y.H., Wu, D., Shen, X., Jiang, H.L.
Keywords : FabZ complex, juglone, Cytoplasm, Lipid A biosynthesis, Lipid synthesis, Lyase
Exp. method : X-RAY DIFFRACTION ( 2.400 Å )
Citation :

Natural product juglone targets three key enzymes from Helicobacter pylori: inhibition assay with crystal structure characterization

Kong, Y.H.,Zhang, L.,Yang, Z.Y.  et al.
(2008)  ACTA PHARMACOL.SIN.  29 : 870 - 876

PubMed: 18565285
DOI: 10.1111/j.1745-7254.2008.00808.x

Reaction

Chain : A, B, C, D, E, F
UniProt : Q5G940 (Q5G940_HELPX)
Reaction: EC: Evidence:
Physiological Direction:
a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O 4.2.1.59 HAMAP-Rule:MF_00406
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