Brand  (β version)

PDB ID: 3B4Y

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Ligands
Code Name Style Show Link
F42 Coenzyme f420 PoSSuM
FLC Citrate anion PoSSuM
Non-standard Residues
Code Name Show
CSO S-hydroxycysteine
MSE Selenomethionine
Glycosylation
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Structure summary

Code : 3B4Y   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : FGD1 (Rv0407) from Mycobacterium tuberculosis
Release Data : 2008-04-22
Compound :
mol_id molecule chains synonym
1 PROBABLE F420-DEPENDENT GLUCOSE-6-PHOSPHATE DEHYDROGENASE FGD1 A,B Glucose-6-phosphate dehydrogenase, F420-dependent
ec: 1.-.-.-
mutation: L243(MSE)
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis H37Rv  (taxid:83332) Mycobacterium smegmatis  (taxid:1772)
strain: H37-Rv
gene: Rv0407
expression_system_strain: mc2 4517
expression_system_vector_type: plasmid
expression_system_plasmid: pYUB1049
Authors : Bashiri, G., Squire, C.J., Moreland, N.M., Baker, E.N., TB Structural Genomics Consortium (TBSGC)
Keywords : TIM-barrel, non-prolyl cis-peptide bulge, F420 binding, Oxidoreductase, Structural Genomics, TB Structural Genomics Consortium, TBSGC
Exp. method : X-RAY DIFFRACTION ( 1.95 Å )
Citation :

Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding

Bashiri, G.,Squire, C.J.,Moreland, N.J.  et al.
(2008)  J.Biol.Chem.  283 : 17531 - 17541

PubMed: 18434308
DOI: 10.1074/jbc.M801854200

Reaction

Chain : A, B
UniProt : P96253
Reaction : -