Brand  (β version)

PDB ID: 3AVY

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CH1 3'-deoxy-cytidine-5'-triphosphate PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 3AVY   PDBj   RCSB PDB   PDBe
Header : TRANSLATION, TRANSFERASE/RNA
Title : Structure of viral RNA polymerase complex 6
Release Data : 2012-01-18
Compound :
mol_id molecule chains
1 Elongation factor Ts, Elongation factor Tu, LINKER, Q beta replicase A
other_details: chimera of Elongation factor Ts, Elongation factor Tu and Q beta replicase
mol_id molecule chains
2 RNA (5'-R(*GP*GP*GP*UP*CP*CP*AP*UP*AP*AP*AP*AP*U)-3') G
mol_id molecule chains
3 RNA (5'-R(*AP*AP*CP*GP*AP*UP*UP*UP*UP*AP*UP*GP*GP*AP*CP*CP*CP*A)-3') T
Source :
mol_id organism_scientific expression_system
1 Escherichia phage Qbeta  (taxid:39803) Escherichia coli  (taxid:562)
mol_id organism_scientific
2
synthetic: yes
mol_id organism_scientific
3
synthetic: yes
Authors : Takeshita, D., Tomita, K.
Keywords : RNA polymerase, TRANSLATION, TRANSFERASE-RNA complex
Exp. method : X-RAY DIFFRACTION ( 2.6160 Å )
Citation :

Molecular basis for RNA polymerization by Q beta replicase

Takeshita, D.,Tomita, K.
(2012)  Nat.Struct.Mol.Biol.  19 : 229 - 237

PubMed: 22245970
DOI: 10.1038/nsmb.2204

Reaction

Chain : A
UniProt : P0A6P3 (EFTS_ECO57)
Reaction : -
Chain : A
UniProt : P0A6N3 (EFTU_ECO57)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + phosphate + H(+) 3.6.5.3 HAMAP-Rule:MF_00118
left-to-right
Chain : A
UniProt : Q8LTE0 (RDRP_BPQBE)
Reaction: EC: Evidence:
Physiological Direction:
RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate 2.7.7.48 PROSITE-ProRule:PRU00539, PubMed:22245970
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:20798060
ECO:0000269 | PubMed:22245970
ECO:0000269 | PubMed:22884418
Binds 2 Mg(2+) per subunit, Ca(2+) is used in crystallization to prevent RNA polymerase activity.