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Ligands
Code Name Style Show Link
CA Calcium ion
FOM 3-[formyl(hydroxy)amino]propylphosphonic acid
MG Magnesium ion
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate
Non-standard Residues
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Code : 3AU9   PDBj   RCSB PDB   PDBe
Header : ISOMERASE/ISOMERASE INHIBITOR
Title : Crystal structure of the quaternary complex-1 of an isomerase
Release Data : 2011-08-10
Compound :
mol_id molecule chains
1 1-deoxy-D-xylulose 5-phosphate reductoisomerase A,B
Source :
mol_id organism_scientific expression_system
1 Plasmodium falciparum  (taxid:5833) Escherichia coli  (taxid:562)
gene: dxr
Authors : Umeda, T., Tanaka, N., Kusakabe, Y., Nakanishi, M., Kitade, Y., Nakamura, K.T.
Keywords : NADPH Binding, ISOMERASE-ISOMERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparum

Umeda, T.,Tanaka, N.,Kusakabe, Y.  et al.
(2011)  Sci Rep  1 : 9 - 9

PubMed: 22355528
DOI: 10.1038/srep00009

Chain : A, B
UniProt : O96693 (DXR_PLAFX)
Reaction: EC: Evidence:
Physiological Direction:
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D- xylulose 5-phosphate + H(+) + NADPH 1.1.1.267 PubMed:10477522
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