Brand  (β version)

PDB ID: 3AEL

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Ligands
Code Name Style Show Link
2LM (2e)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]-4-(methylsulfanyl)butanoic acid PoSSuM
4LM (2e)-2-{[(1e)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}but-2-enoic acid PoSSuM
GOL Glycerol PoSSuM
MEE Methanethiol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3AEL   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Reaction intermediate structure of Entamoeba histolytica methionine gamma-lyase 1 containing methionine imine-pyridoxamine-5'-phosphate and alpha-amino-alpha, beta-butenoic acid-pyridoxal-5'-phosphate
Release Data : 2011-02-09
Compound :
mol_id molecule chains
1 Methionine gamma-lyase A,B,C,D
ec: 4.4.1.11
Source :
mol_id organism_scientific expression_system
1 Entamoeba histolytica  (taxid:5759) Escherichia coli  (taxid:562)
gene: metg
expression_system_strain: BL21 (DE3)
expression_system_vector_type: VECTOR
expression_system_vector: pGEX6P1
Authors : Karaki, T., Sato, D., Shimizu, A., Nozaki, T., Harada, S.
Keywords : gamma-lyase, L-methionine, entamoeba histolytica, lyase
Exp. method : X-RAY DIFFRACTION ( 2.000 Å )
Citation :

Crystal structure of Entamoeba histolytica methionine gamma-lyase 1

Karaki, T.,Sato, D.,Shimizu, A.  et al.
To be Published 

Reaction

Chain : A, B, C, D
UniProt : Q86D28 (Q86D28_ENTHI)
Reaction: EC: Evidence:
Physiological Direction:
O-phospho-L-homoserine + L-cysteine = L,L-cystathionine + phosphate 2.5.1.160 ARBA:ARBA00093261
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O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+) - ARBA:ARBA00093222
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Cofactor: Evidence: Note:
pyridoxal 5'-phosphate ECO:0000256 | ARBA:ARBA00001933
ECO:0000256 | RuleBase:RU362118
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