Brand  (β version)

PDB ID: 3ABA

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
FLI (3r,4s,6s,8s,10r,12r,14r,16s,17e,19e,21e,23e,25e,28r)-3-hexyl-4,6,8,10,12,14,16-heptahydroxy-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 3ABA   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/ANTIBIOTIC
Title : Crystal structure of CYP105P1 in complex with filipin I
Release Data : 2010-04-07
Compound :
mol_id molecule chains synonym
1 Cytochrome P450 A Cytochrome P450 hydroxylase, CYP105P1
ec: 1.14.13.-
Source :
mol_id organism_scientific expression_system
1 Streptomyces avermitilis  (taxid:33903) Escherichia coli  (taxid:562)
strain: MA-4680
gene: pteC, SAV413, SAV_413
expression_system_strain: BL21 Codonplus (DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pET17b
Authors : Xu, L.H., Fushinobu, S., Takamatsu, S., Wakagi, T., Ikeda, H., Shoun, H.
Keywords : P450, oxidoreductase, heme, monooxygenase, macrolide, filipin, Iron, Metal-binding, OXIDOREDUCTASE-ANTIBIOTIC complex
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Regio- and stereospecificity of filipin hydroxylation sites revealed by crystal structures of cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis

Xu, L.H.,Fushinobu, S.,Takamatsu, S.  et al.
(2010)  J.Biol.Chem.  285 : 16844 - 16853

PubMed: 20375018
DOI: 10.1074/jbc.M109.092460

Crystal structures of cytochrome P450 105P1 from Streptomyces avermitilis: conformational flexibility and histidine ligation state

Xu, L.H.,Fushinobu, S.,Ikeda, H.  et al.
(2009)  J.Bacteriol.  191 : 1211 - 1219

PubMed: 19074393
DOI: 10.1128/JB.01276-08

Reaction

Chain : A
UniProt : Q93H81 (Q93H81_STRAX)
Reaction : -