Brand  (β version)

PDB ID: 2ZT8

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Ligands
Code Name Style Show Link
DRV [(2s,3r,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (aminoacetyl)sulfamate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2ZT8   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with Gly-AMP analog
Release Data : 2009-08-25
Compound :
mol_id molecule chains synonym
1 Glycyl-tRNA synthetase A Glycine-tRNA ligase, GlyRS
ec: 6.1.1.14
fragment: UNP residues 55-739
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: GARS
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pET21a
Authors : Guo, R.T., Yang, X.L., Schimmel, P.
Keywords : Ligase, AP4A, Glycine, ATP, Gly-AMP, tRNA, Aminoacyl-tRNA synthetase, ATP-binding, Charcot-Marie-Tooth disease, Disease mutation, Nucleotide-binding, Phosphoprotein, Protein biosynthesis
Exp. method : X-RAY DIFFRACTION ( 3.35 Å )
Citation :

Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis

Guo, R.T.,Chong, Y.E.,Guo, M.  et al.
To be Published 

Reaction

Chain : A
UniProt : P41250 (GARS_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl- tRNA(Gly) 6.1.1.14 PubMed:17544401, PubMed:24898252, PubMed:28675565
left-to-right PubMed:24898252
2 ATP + H(+) = diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate - PubMed:19710017
left-to-right