Brand  (β version)

PDB ID: 2Z50

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Ligands
Code Name Style Show Link
028 (1-hydroxyheptane-1,1-diyl)bis(phosphonic acid) PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2Z50   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with BPH-28
Release Data : 2008-07-01
Compound :
mol_id molecule chains synonym
1 Geranylgeranyl pyrophosphate synthetase A,B GGPP synthetase, GGPPSase, Geranylgeranyl diphosphate synthase, BET2 suppressor protein 1
ec: 2.5.1.30, 2.5.1.1, 2.5.1.10, 2.5.1.29
Source :
mol_id organism_scientific organism_common expression_system
1 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pET32 Xa/LIC
Authors : Guo, R.T., Chen, C.K.-M., Hudock, M., Cao, R., Oldfield, E., Wang, A.H.-J.
Keywords : prenyltransferase, geranylgeranyl pyrophosphate, bisphosphonate, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.01 Å )
Citation :

Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation

Chen, C.K.-M.,Hudock, M.P.,Zhang, Y.  et al.
(2008)  J.Med.Chem.  51 : 5594 - 5607

PubMed: 18800762
DOI: 10.1021/jm800325y

Reaction

Chain : A, B
UniProt : Q12051 (GGPPS_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
dimethylallyl diphosphate + isopentenyl diphosphate = (2E)- geranyl diphosphate + diphosphate 2.5.1.1 -
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(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)- farnesyl diphosphate + diphosphate 2.5.1.10 -
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(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate 2.5.1.29 PubMed:7665600
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