Brand  (β version)

PDB ID: 2Z3U

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Ligands
Code Name Style Show Link
CRR 3,4-di-1h-indol-3-yl-1h-pyrrole-2,5-dicarboxylic acid PoSSuM
EDO 1,2-ethanediol PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
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Structure summary

Code : 2Z3U   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure of Chromopyrrolic Acid Bound Cytochrome P450 StaP (CYP245A1)
Release Data : 2007-07-03
Compound :
mol_id molecule chains
1 Cytochrome P450 A
ec: 1.-.-.-
Source :
mol_id organism_scientific expression_system
1 Streptomyces sp. TP-A0274  (taxid:171258) Escherichia coli BL21(DE3)  (taxid:469008)
gene: staP
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pET26b
Authors : Makino, M., Sugimoto, H., Shiro, Y., Asamizu, S., Onaka, H., Nagano, S.
Keywords : cytochrome P450, monoxygenase, oxydoreductase, heme-enzyme, chromopyrrolic acid, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton

Makino, M.,Sugimoto, H.,Shiro, Y.  et al.
(2007)  Proc.Natl.Acad.Sci.Usa  104 : 11591 - 11596

PubMed: 17606921
DOI: 10.1073/pnas.0702946104

Theoretical and experimental studies of the conversion of chromopyrrolic acid to an antitumor derivative by cytochrome P450 StaP: the catalytic role of water molecules

Wang, Y.,Chen, H.,Makino, M.  et al.
(2009)  J.Am.Chem.Soc.  131 : 6748 - 6762

PubMed: 19385626
DOI: 10.1021/ja9003365

Reaction

Chain : A
UniProt : Q83WG3 (Q83WG3_9ACTN)
Reaction : -