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Ligands
Code Name Style Show Link
CXD 4-chloranyl-N-[[4-chloranyl-3-(3-chloranyl-5-cyano-phenoxy)-2-fluoranyl-phenyl]methyl]-1h-imidazole-5-carboxamide
MG Magnesium ion
TAR D(-)-tartaric acid
Non-standard Residues
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Glycosylation
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Modification
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Code : 2YNI   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : HIV-1 Reverse Transcriptase in complex with inhibitor GSK952
Release Data : 2013-01-09
Compound :
mol_id molecule chains synonym
1 REVERSE TRANSCRIPTASE/RIBONUCLEASE H A EXORIBONUCLEASE H, P66 RT
ec: 2.7.7.49, 2.7.7.7, 3.1.26.13, 3.1.13.2
mol_id molecule chains
2 P51 RT B
fragment: RESIDUES 588-1015
Source :
mol_id organism_scientific organism_common expression_system
1 HIV-1 M\:B_HXB2R  (taxid:11706) HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HXB2 ISOLATE) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PKK233-2 VARIANT
mol_id organism_scientific organism_common expression_system
2 HIV-1 M\:B_HXB2R  (taxid:11706) HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HXB2 ISOLATE) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PKK233-2 VARIANT
Authors : Chong, P., Sebahar, P., Youngman, M., Garrido, D., Zhang, H., Stewart, E.L., Nolte, R.T., Wang, L., Ferris, R.G., Edelstein, M., Weaver, K., Mathis, A., Peat, A.
Keywords : HYDROLASE, NNRTI
Exp. method : X-RAY DIFFRACTION ( 2.49 Å )
Citation :

Rational Design of Potent Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase.

Chong, P.,Sebahar, P.,Youngman, M.  et al.
(2012)  J.Med.Chem.  55 : 10601

PubMed: 23137340
DOI: 10.1021/JM301294G

Chain : B
UniProt : P04585 (POL_HV1H2)
Reaction: EC: Evidence:
Physiological Direction:
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro. 3.4.23.16 PROSITE-ProRule:PRU00275, PubMed:32053707, PubMed:33542150
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Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 3.1.26.13 UniProtKB:P03366
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3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. 3.1.13.2 -
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.49 PROSITE- ProRule:PRU00405
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PROSITE- ProRule:PRU00405
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