Brand  (β version)

PDB ID: 2YAC

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Ligands
Code Name Style Show Link
937 1-(2-hydroxyethyl)-8-[[5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl]amino]-4,5-dihydropyrimido[5,4-G]indazole-3-carboxamide PoSSuM
TLA L(+)-tartaric acid PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 2YAC   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of Polo-like kinase 1 in complex with NMS-P937
Release Data : 2011-04-06
Compound :
mol_id molecule chains synonym
1 SERINE/THREONINE-PROTEIN KINASE PLK1 A POLO-LIKE KINASE 1, PLK-1, SERINE/THREONINE-PROTEIN KINASE 13, STPK13, PLK1 KINASE
ec: 2.7.11.21
fragment: KINASE DOMAIN RESIDUES 36-345
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_cell_line: High Five
expression_system_vector_type: BACULOVIRUS
Authors : Bertrand, J.A., Bossi, R.T.
Keywords : TRANSFERASE, ATP-BINDING, CELL CYCLE, CELL DIVISION, MITOSIS, NUCLEOTIDE-BINDING, NUCLEUS
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Nms-P937, a 4,5-Dihydro-1H-Pyrazolo[4,3-H]Quinazoline Derivative as Potent and Selective Polo-Like Kinase 1 Inhibitor.

Beria, I.,Bossi, R.T.,Brasca, M.G.  et al.
(2011)  Bioorg.Med.Chem.Lett.  21 : 2969

PubMed: 21470862
DOI: 10.1016/J.BMCL.2011.03.054

Reaction

Chain : A
UniProt : P53350 (PLK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.21 PubMed:11202906, PubMed:12207013, PubMed:21880710, PubMed:22325354, PubMed:37440612, PubMed:37674080
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.21 PubMed:11202906, PubMed:12207013, PubMed:21880710, PubMed:37674080
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