Brand  (β version)

PDB ID: 2YA3

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Ligands
Code Name Style Show Link
AMP Adenosine monophosphate PoSSuM
J7V 3'-(7-diethylaminocoumarin-3-carbonylamino)-3'-deoxy-ADP PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 2YA3   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : STRUCTURE OF THE REGULATORY FRAGMENT OF MAMMALIAN AMPK IN COMPLEX WITH COUMARIN ADP
Release Data : 2011-03-16
Compound :
mol_id molecule chains synonym
1 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1 A AMPK SUBUNIT ALPHA-1
ec: 2.7.11.1
fragment: RESIDUES 407-555
other_details: THE RESIDUES FROM A 393-395 AND 545-550 ARE ARTIFICIAL AS A RESULT OF CLONING STRATEGY
mol_id molecule chains synonym
2 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2 B AMPK SUBUNIT BETA-2
fragment: RESIDUES 187-272
mol_id molecule chains synonym
3 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1 E AMPK SUBUNIT ALPHA-1, AMPK GAMMA1, AMPK SUBUNIT GAMMA-1, AMPKG
fragment: RESIDUES 1-330
Source :
mol_id organism_scientific organism_common expression_system
1 RATTUS NORVEGICUS  (taxid:10116) NORWAY RAT ESCHERICHIA COLI  (taxid:562)
mol_id organism_scientific organism_common expression_system
2 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
mol_id organism_scientific organism_common expression_system
3 RATTUS NORVEGICUS  (taxid:10116) NORWAY RAT ESCHERICHIA COLI  (taxid:562)
Authors : Xiao, B., Sanders, M.J., Underwood, E., Heath, R., Mayer, F., Carmena, D., Jing, C., Walker, P.A., Eccleston, J.F., Haire, L.F., Saiu, P., Howell, S.A., Aasland, R., Martin, S.R., Carling, D., Gamblin, S.J.
Keywords : TRANSFERASE, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, PHOSPHORYLATION
Exp. method : X-RAY DIFFRACTION ( 2.51 Å )
Citation :

Structure of Mammalian Ampk and its Regulation by Adp

Xiao, B.,Sanders, M.J.,Underwood, E.  et al.
(2011)  Nature  472 : 230

PubMed: 21399626
DOI: 10.1038/NATURE09932

Reaction

Chain : A
UniProt : P54645 (AAPK1_RAT)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:2369897, PubMed:9029219
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:2369897, PubMed:9029219
-
ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O- phospho-L-seryl-[acetyl-CoA carboxylase] - PubMed:9029219
-
ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] = ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3- methylglutaryl-coenzyme A reductase] 2.7.11.31 PubMed:2369897
-
ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl- [tau protein] 2.7.11.26 PubMed:21204788
-
ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L- threonyl-[tau protein] 2.7.11.26 PubMed:21204788
-
Chain : B
UniProt : O43741 (AAKB2_HUMAN)
Reaction : -
Chain : E
UniProt : P80385 (AAKG1_RAT)
Reaction : -