PDB ID: 2XYE
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|Title :||HIV-1 Inhibitors with a Tertiary-Alcohol-containing Transition-State Mimic and various P2 and P1 prime Substituents|
|Release Data :||2011-12-07|
|Authors :||Ohrngren, P., Wu, X., Persson, M., Ekegren, J.K., Wallberg, H., Rosenquist, A., Samuelsson, B., Unge, T., Larhed, M.|
|Keywords :||HYDROLASE, AIDS|
|Exp. method :||X-RAY DIFFRACTION ( 2.00 Å )|
HIV-1 Protease Inhibitors with a Tertiary Alcohol Containing Transition-State Mimic and Various P2 and P1' Substituents
Ohrngren, P.,Wu, X.,Persson, M.
|Chain :||A, B|
|UniProt :||P03366 (POL_HV1B1)|
|Reaction :||Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).