PDB ID: 2XXI
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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GLU | Glutamic acid | PoSSuM | |||
JAC | 1-({4-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-C]pyrazol-1(4h)-yl]phenyl}methyl)-2-pyrrolidinone | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM | |||
ZN | Zinc ion | PoSSuM |
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Download interaction data: 2XXI
Structure summary
Code : | 2XXI PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSPORT PROTEIN | ||||||||||||
Title : | Crystal structure of 1-((4-(3-(trifluoromethyl)-6,7-dihydropyrano(4,3- C(pyrazol-1(4H)-yl)phenyl)methyl)-2-pyrrolidinone in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.6A resolution. | ||||||||||||
Release Data : | 2011-04-06 | ||||||||||||
Compound : |
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Source : |
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Authors : | Ward, S.E., Harries, M., Aldegheri, L., Austin, N.E., Ballantine, S., Ballini, E., Bradley, D.M., Bax, B.D., Clarke, B.P., Harris, A.J., Harrison, S.A., Melarange, R.A., Mookherjee, C., Mosley, J., DalNegro, G., Oliosi, B., Smith, K.J., Thewlis, K.M., Woollard, P.M., Yusaf, S.P. | ||||||||||||
Keywords : | TRANSPORT PROTEIN, AMPA RECEPTOR LIGAND-BINDING CORE, ION CHANNEL | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.60 Å ) | ||||||||||||
Citation : |
Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of Ampa Receptor Positive Allosteric Modulators.
Ward, S.E.,Harries, M.,Aldegheri, L.
et al.
PubMed: 21128618 |
Reaction
Chain : | A, B, C |
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UniProt : | P19491 (GRIA2_RAT) |
Reaction : | - |