Brand  (β version)

PDB ID: 2XRZ

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
SO4 Sulfate ion PoSSuM
GOL Glycerol PoSSuM
ACT Acetate ion PoSSuM
Non-standard Residues
Code Name Show
TT [(1r,3r,4s,9r,10s,12r,15as,15br,18br,18cs)-10-hydroxy-15a,15b-dimethyl-13,15,16,18-tetraoxohexadecahydro-8h-9,12-epoxy-1,4-methano-2,5,7-trioxa-12a,14,17,18a-tetraazacyclohexadeca[1,2,3,4-def]biphenylen-3-yl]methyl dihydrogen phosphate
Glycosylation
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Structure summary

Code : 2XRZ   PDBj   RCSB PDB   PDBe
Header : LYASE/DNA
Title : X-ray structure of archaeal class II CPD photolyase from Methanosarcina mazei in complex with intact CPD-lesion
Release Data : 2011-09-14
Compound :
mol_id molecule chains synonym
1 DEOXYRIBODIPYRIMIDINE PHOTOLYASE A,B CLASS II CPD PHOTOLYASE
ec: 4.1.99.3
fragment: RESIDUES 3-464
mutation: YES
mol_id molecule chains
2 CPD-COMPRISING OLIGONUCLEOTIDE C,E
other_details: OLIGONUCLEOTIDE WITH A SYNTHETIC FORMACETAL- LINKED THYMINE DIMER
mol_id molecule chains
3 COUNTERSTRAND-OLIGONUCLEOTIDE D,F
Source :
mol_id organism_scientific expression_system
1 METHANOSARCINA MAZEI  (taxid:192952) ESCHERICHIA COLI  (taxid:469008)
strain: GO1
expression_system_strain: BL21(DE3)
expression_system_variant: GOLD
expression_system_vector_type: PLASMID
expression_system_vector: PET28A
mol_id organism_scientific
2 SYNTHETIC CONSTRUCT  (taxid:32630)
synthetic: yes
mol_id organism_scientific
3 SYNTHETIC CONSTRUCT  (taxid:32630)
synthetic: yes
Authors : Kiontke, S., Geisselbrecht, Y., Pokorny, R., Carell, T., Batschauer, A., Essen, L.O.
Keywords : LYASE-DNA COMPLEX, PHOTOLYASE, DNA DAMAGE, DNA REPAIR, CLASS II, INTACT CPD-LESION, PROTEIN-DNA COMPLEX, WATER CLUSTER
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Crystal Structures of an Archaeal Class II DNA Photolyase and its Complex with Uv-Damaged Duplex DNA.

Kiontke, S.,Geisselbrecht, Y.,Pokorny, R.  et al.
(2011)  Embo J.  30 : 4437

PubMed: 21892138
DOI: 10.1038/EMBOJ.2011.313

Reaction

Chain : A, B
UniProt : Q8PYK9 (Q8PYK9_METMA)
Reaction: EC: Evidence:
Physiological Direction:
cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). 4.1.99.3 ARBA:ARBA00033999
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