Brand  (β version)

PDB ID: 2XQG

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Ligands
Code Name Style Show Link
BR Bromide ion PoSSuM
CA Calcium ion PoSSuM
CL Chloride ion PoSSuM
GLY Glycine PoSSuM
NA Sodium ion PoSSuM
SO4 Sulfate ion PoSSuM
UNX Unknown atom or ion PoSSuM
VR 2-methylpropyl hydrogen (R)-methylphosphonate PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
FUL Beta-L-fucopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 2XQG   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : X-ray Structure of human butyrylcholinesterase inhibited by racemic VR
Release Data : 2011-03-23
Compound :
mol_id molecule chains synonym
1 CHOLINESTERASE A ACYLCHOLINE ACYLHYDROLASE, CHOLINE ESTERASE II, BUTYRYLCHOLINE ESTERASE, PSEUDOCHOLINESTERASE
ec: 3.1.1.8
fragment: RESIDUES 31-557
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN CRICETULUS GRISEUS  (taxid:10029)
expression_system_common: CHINESE HAMSTER
expression_system_cell_line: CHO K1
expression_system_plasmid: PGS
Authors : Wandhammer, M., Carletti, E., Gillon, E., Masson, P., Goeldner, M., Noort, D., Nachon, F.
Keywords : HYDROLASE, NERVE AGENT, BIOSCAVENGER
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Structural Study of the Complex Stereoselectivity of Human Butyrylcholinesterase for the Neurotoxic V-Agents.

Wandhammer, M.,Carletti, E.,Van Der Schans, M.  et al.
(2011)  J.Biol.Chem.  286 : 16783

PubMed: 21454498
DOI: 10.1074/JBC.M110.209569

Reaction

Chain : A
UniProt : P06276 (CHLE_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
an acylcholine + H2O = a carboxylate + choline + H(+) 3.1.1.8 PubMed:19368529, PubMed:19452557
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