Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CA Calcium ion
EDO 1,2-ethanediol
F6Z 3',6'-dihydroxy-3-oxo-3h-spiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acid
T44 3,5,3',5'-tetraiodo-L-thyronine
Code : 2XN7
Header : TRANSPORT
Title : Crystal structure of thyroxine-binding globulin complexed with thyroxine-fluoresein (T405-CF)
Release Data : 2011-02-16
Compound :
mol_id molecule chains synonym
1 THYROXINE-BINDING GLOBULIN A T4-BINDING GLOBULIN, SERPIN A7
fragment: RESIDUES 32-380
mutation: YES
other_details: RESIDUES 346-355 OF TBG WERE REPLACED BY GAMFLEAIPRS
mol_id molecule chains synonym
2 THYROXINE-BINDING GLOBULIN B T4-BINDING GLOBULIN, SERPIN A7
fragment: RESIDUES 381-415
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_vector: PSUMO3
mol_id organism_scientific organism_common expression_system
2 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_vector: PSUMO3
Authors : Qi, X., Yan, Y., Wei, Z., Zhou, A.
Keywords : TRANSPORT, CLEAVED PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.43 Å )
Citation :

Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid Binding-Globulins.

Qi, X.,Loiseau, F.,Chan, W.L.  et al.
(2011)  J.Biol.Chem.  286 : 16163

PubMed: 21325280
DOI: 10.1074/JBC.M110.171082

Chain : B
UniProt : P05543 (THBG_HUMAN)
Reaction : -