Brand  (β version)

PDB ID: 2XMY

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Ligands
Code Name Style Show Link
CDK 4-[4-(3,4-dimethyl-2-oxo-2,3-dihydro-thiazol-5-yl)-pyrimidin-2-ylamino]-N-(2-methoxy-ethyl)-benzenesulfonamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2XMY   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Discovery and Characterisation of 2-Anilino-4-(thiazol-5-yl) pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents
Release Data : 2010-11-10
Compound :
mol_id molecule chains synonym
1 CELL DIVISION PROTEIN KINASE 2 A P33 PROTEIN KINASE
ec: 2.7.1.37, 2.7.11.22
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_cell_line: SF9
expression_system_vector_type: BACULOVIRUS
Authors : Wang, S., Griffiths, G., Midgley, C.A., Barnett, A.L., Cooper, M., Grabarek, J., Ingram, L., Jackson, W., Kontopidis, G., McClue, S.J., McInnes, C., McLachlan, J., Meades, C., Mezna, M., Stuart, I., Thomas, M.P., Zheleva, D.I., Lane, D.P., Jackson, R.C., Glover, D.M., Blake, D.G., Fischer, P.M.
Keywords : CELL CYCLE, TRANSFERASE, CDK9 INHIBITOR
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Discovery and Characterisation of 2-Anilino-4-(Thiazol-5-Yl)Pyrimidine Transcriptional Cdk Inhibitors as Anticancer Agents

Wang, S.,Griffiths, G.,Midgley, C.A.  et al.
(2010)  Chem.Biol.  17 : 1111

PubMed: 21035734
DOI: 10.1016/J.CHEMBIOL.2010.07.016

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.22 PubMed:1396589, PubMed:24670654, PubMed:28216226, PubMed:28666995, PubMed:9030781
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.22 PubMed:1396589, PubMed:24670654, PubMed:28666995, PubMed:9030781
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:21565702
Binds 2 Mg(2+) ions.