Het-PDB Navi2 (PDB: 2XJ2)

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Ligands
Code	Name		Style	Show	Link
985	(2e)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2-yl]phenyl}prop-2-enoic acid				PoSSuM

Non-standard Residues
Code	Name	Show
SEP	Phosphoserine

Glycosylation
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Download interaction data: 2XJ2

Code :

2XJ2 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Protein kinase Pim-1 in complex with small molecule inhibitor

Release Data :

2011-02-23

Compound :

mol_id	molecule	chains
1	PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1	A
	ec: 2.7.11.1 fragment: KINASE DOMAIN, RESIDUES 14-313

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:562)
	gene: PIM1 expression_system_vector_type: PLASMID expression_system_plasmid: PET30A

Authors :

Schulz, M.N., Fanghanel, J., Schafer, M., Badock, V., Briem, H., Boemer, U., Nguyen, D., Husemann, M., Hillig, R.C.

Keywords :

TRANSFERASE, PHOSPHORYLATION, PROTEIN KINASE FOLD

Exp. method :

X-RAY DIFFRACTION ( 2.20 Å )

Citation :

Crystallographic Fragment Screen Identifies Cinnamic Acid Derivatives as Starting Points for Potent Pim-1 Inhibitors

Schulz, M.N.,Fanghanel, J.,Schafer, M. et al.
(2011) Acta Crystallogr.,Sect.D 67 : 156

Chain :

UniProt :

P11309 (PIM1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.1	PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:31548394
	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.1	PubMed:15525646, PubMed:15657054, PubMed:15808862
	-	PubMed:15525646, PubMed:15657054, PubMed:15808862

PDB ID: 2XJ2