Brand  (β version)

PDB ID: 2XJ2

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Ligands
Code Name Style Show Link
985 (2e)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2-yl]phenyl}prop-2-enoic acid PoSSuM
Non-standard Residues
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SEP Phosphoserine
Glycosylation
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Structure summary

Code : 2XJ2   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Protein kinase Pim-1 in complex with small molecule inhibitor
Release Data : 2011-02-23
Compound :
mol_id molecule chains
1 PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1 A
ec: 2.7.11.1
fragment: KINASE DOMAIN, RESIDUES 14-313
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
gene: PIM1
expression_system_vector_type: PLASMID
expression_system_plasmid: PET30A
Authors : Schulz, M.N., Fanghanel, J., Schafer, M., Badock, V., Briem, H., Boemer, U., Nguyen, D., Husemann, M., Hillig, R.C.
Keywords : TRANSFERASE, PHOSPHORYLATION, PROTEIN KINASE FOLD
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Crystallographic Fragment Screen Identifies Cinnamic Acid Derivatives as Starting Points for Potent Pim-1 Inhibitors

Schulz, M.N.,Fanghanel, J.,Schafer, M.  et al.
(2011)  Acta Crystallogr.,Sect.D  67 : 156

PubMed: 21358046
DOI: 10.1107/S0907444910054144

Reaction

Chain : A
UniProt : P11309 (PIM1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:31548394, PubMed:37797010
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:37797010
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:15525646
ECO:0000269 | PubMed:15657054
ECO:0000269 | PubMed:15808862
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