Brand  (β version)

PDB ID: 2WPO

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Ligands
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01E (2s)-2-(3,3-dimethylbutanoylamino)-N-[(2s)-1-[[(2s,3s)-3-hydroxy-4-[(4-iodophenyl)methylamino]-4-oxo-butan-2-yl]amino]- 1,4-dioxo-4-pyrrol-1-yl-butan-2-yl]-3,3-dimethyl-butanamide PoSSuM
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Structure summary

Code : 2WPO   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : HCMV protease inhibitor complex
Release Data : 1999-08-04
Compound :
mol_id molecule chains
1 HUMAN CYTOMEGALOVIRUS PROTEASE A,B,C,D
ec: 3.4.21.-
mutation: A143Q, T181M, L229M
Source :
mol_id organism_scientific organism_common expression_system
1 Human herpesvirus 5  (taxid:10359) Human cytomegalovirus Escherichia coli  (taxid:562)
Authors : Tong, L., Qian, C., Massariol, M.-J., Deziel, R., Yoakim, C., Lagace, L.
Keywords : VIRAL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR complex, COAT PROTEIN, SERINE PROTEASE
Exp. method : X-RAY DIFFRACTION ( 2.7 Å )
Citation :

Conserved mode of peptidomimetic inhibition and substrate recognition of human cytomegalovirus protease.

Tong, L.,Qian, C.,Massariol, M.J.  et al.
(1998)  Nat.Struct.Biol.  5 : 819 - 826

PubMed: 9731777
DOI: 10.1038/1860

A New Serine-Protease Fold Revealed by the Crystal Structure of Human Cytomegalovirus Protease

Tong, L.,Qian, C.,Massariol, M.J.  et al.
(1996)  Nature  383 : 272

Reaction

Chain : A, B, C, D
UniProt : P16753 (SCAF_HCMVA)
Reaction: EC: Evidence:
Physiological Direction:
Cleaves -Ala-|-Ser- and -Ala-|-Ala- bonds in the scaffold protein. 3.4.21.97 HAMAP-Rule:MF_04008
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