Brand  (β version)

PDB ID: 2WEV

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Ligands
Code Name Style Show Link
CK7 [4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amine PoSSuM
Non-standard Residues
Code Name Show
B3L (3s)-3-amino-5-methylhexanoic acid
MEA N-methylphenylalanine
Glycosylation
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Modification
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ACE Acetyl group
NH2 Amino group

Structure summary

Code : 2WEV   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design
Release Data : 2009-06-09
Compound :
mol_id molecule chains synonym
1 CELL DIVISION PROTEIN KINASE 2 A,C CYCLIN-DEPENDENT KINASE 2, P33 PROTEIN KINASE
ec: 2.7.1.37
other_details: TRIAZOL-1-METHYL-PYRIMIDIN INHIBITOR
mol_id molecule chains synonym
2 CYCLIN-A2 B,D CYCLIN-A
fragment: RESIDUES 173-432
other_details: CAP-TETRAPEPTIDE INHIBITOR
mol_id molecule chains
3 ARG-ARG-B3L-MEA E,F
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_cell_line: SF9
expression_system_vector_type: BACULOVIRUS
mol_id organism_scientific organism_common expression_system
2 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
mol_id organism_scientific
3 SYNTHETIC CONSTRUCT  (taxid:32630)
synthetic: yes
Authors : Kontopidis, G., Andrews, M.J., McInnes, C., Plater, A., Innes, L., Renachowski, S., Cowan, A., Fischer, P.M.
Keywords : CDK2, KINASE, CYCLIN, ACTIVE, NUCLEUS, MITOSIS, SERINE/THREONINE-PROTEIN KINASE, CYTOPLASM, INHIBITION, CELL CYCLE, ATP-BINDING, CELL DIVISION, PHOSPHOPROTEIN, NUCLEOTIDE-BINDING, TRANSFERASE, POLYMORPHISM, BETA-PEPTIDE, CYCLIN GROOVE
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Truncation and Optimisation of Peptide Inhibitors of Cyclin-Dependent Kinase 2-Cyclin a Through Structure-Guided Design.

Kontopidis, G.,Andrews, M.J.,Mcinnes, C.  et al.
(2009)  Chemmedchem  4 : 1120

PubMed: 19472269
DOI: 10.1002/CMDC.200900093

Reaction

Chain : A, C
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
-
Chain : B, D
UniProt : P20248 (CCNA2_HUMAN)
Reaction : -