Brand  (β version)

PDB ID: 2W3L

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Ligands
Code Name Style Show Link
DRO 1-(2-{[(3s)-3-(aminomethyl)-3,4-dihydroisoquinolin-2(1h)-yl]carbonyl}phenyl)-4-chloro-5-methyl-N,N-diphenyl-1h-pyrazole-3-carboxamide PoSSuM
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Structure summary

Code : 2W3L   PDBj   RCSB PDB   PDBe
Header : APOPTOSIS
Title : Crystal Structure of Chimaeric Bcl2-xL and Phenyl Tetrahydroisoquinoline Amide Complex
Release Data : 2008-12-09
Compound :
mol_id molecule chains synonym
1 APOPTOSIS REGULATOR BCL-2 A,B BCL2-XL
fragment: RESIDUES 9-33,92-206
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
Authors : Porter, J., Payne, A., de Candole, B., Ford, D., Hutchinson, B., Trevitt, G., Turner, J., Edwards, C., Watkins, C., Whitcombe, I., Davis, J., Stubberfield, C., Fisher, M., Lamers, M.
Keywords : APOPTOSIS
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Tetrahydroisoquinoline Amide Substituted Phenyl Pyrazoles as Selective Bcl-2 Inhibitors.

Porter, J.,Payne, A.,De Candole, B.  et al.
(2009)  Bioorg.Med.Chem.Lett.  19 : 230

PubMed: 19027294
DOI: 10.1016/J.BMCL.2008.10.113

Reaction

Chain : A, B
UniProt : P10415 (BCL2_HUMAN)
Reaction : -