Brand  (β version)

PDB ID: 2W0U

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Ligands
Code Name Style Show Link
C7C 5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole-4-carboxylate PoSSuM
FMN Flavin mononucleotide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2W0U   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : CRYSTAL STRUCTURE OF HUMAN GLYCOLATE OXIDASE IN COMPLEX WITH THE INHIBITOR 5-[(4-CHLOROPHENYL)SULFANYL]- 1,2,3-THIADIAZOLE-4-CARBOXYLATE.
Release Data : 2009-11-10
Compound :
mol_id molecule chains synonym
1 HYDROXYACID OXIDASE 1 A,B,C,D GLYCOLATE OXIDASE, HAOX1, GOX
ec: 1.1.3.15
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:511693)
organ: LIVER
expression_system_strain: BL21
expression_system_plasmid: PTRCHISB
Authors : Bourhis, J.M., Lindqvist, Y.
Keywords : FLAVOPROTEIN, GLYCOLATE PATHWAY, HYDROXYACID OXIDASE 1, OXIDOREDUCTASE, PEROXISOME, INHIBITOR
Exp. method : X-RAY DIFFRACTION ( 2.84 Å )
Citation :

Structure of Human Glycolate Oxidase in Complex with the Inhibitor 4-Carboxy-5-[(4-Chlorophenyl)Sulfanyl]-1,2,3-Thiadiazole.

Bourhis, J.M.,Vignaud, C.,Pietrancosta, N.  et al.
(2009)  Acta Crystallogr.,Sect.F  65 : 1246

PubMed: 20054120
DOI: 10.1107/S1744309109041670

Reaction

Chain : A, B, C, D
UniProt : Q9UJM8 (HAOX1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2 1.1.3.15 PubMed:10777549, PubMed:17669354, PubMed:18215067
left-to-right PubMed:10777549
glycolate + O2 = glyoxylate + H2O2 1.1.3.15 PubMed:10777549, PubMed:10978532, PubMed:17669354, PubMed:18215067
left-to-right PubMed:10978532, PubMed:17669354
glyoxylate + H2O + O2 = H(+) + H2O2 + oxalate 1.2.3.5 PubMed:10777549, PubMed:17669354, PubMed:18215067
left-to-right PubMed:17669354
2-hydroxyhexadecanoate + O2 = 2-oxohexadecanoate + H2O2 - PubMed:10777549, PubMed:18215067
left-to-right PubMed:10777549
2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2 - PubMed:10777549, PubMed:18215067
left-to-right PubMed:10777549