Brand  (β version)

PDB ID: 2W06

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Ligands
Code Name Style Show Link
FRV 4-{[4-(1-cyclopropyl-2-methyl-1h-imidazol-5-yl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide PoSSuM
Non-standard Residues
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Glycosylation
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ACE Acetyl group

Structure summary

Code : 2W06   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure of CDK2 in complex with an imidazolyl pyrimidine, compound 5c
Release Data : 2008-09-23
Compound :
mol_id molecule chains synonym
1 CELL DIVISION PROTEIN KINASE 2 A P33 PROTEIN KINASE, CDK2
ec: 2.7.11.22
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_cell_line: Sf21
expression_system_vector_type: BACULOVIRUS
Authors : Anderson, M., Andrews, D.M., Barker, A.J., Brassington, C.A., Byth, K.F., Culshaw, J.D., Finlay, M.R.V., Fisher, E., Mcmiken, H.H.J., Green, C.P., Heaton, D.W., Nash, I.A., Newcombe, N.J., Oakes, S.E., Roberts, A., Stanway, J.J., Thomas, A.P., Tucker, J.A., Weir, H.M.
Keywords : KINASE, MITOSIS, CELL CYCLE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, POLYMORPHISM, CELL DIVISION, PHOSPHOPROTEIN, PHOSPHORYLATION, NUCLEOTIDE-BINDING
Exp. method : X-RAY DIFFRACTION ( 2.04 Å )
Citation :

Imidazoles: Sar and Development of a Potent Class of Cyclin-Dependent Kinase Inhibitors

Anderson, M.,Andrews, D.M.,Barker, A.J.  et al.
(2008)  Bioorg.Med.Chem.Lett.  18 : 5487

PubMed: 18815031
DOI: 10.1016/J.BMCL.2008.09.024

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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