Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
FRT N-(2-methoxyethyl)-4-({4-[2-methyl-1-(1-methylethyl)-1h-imidazol-5-yl]pyrimidin-2-yl}amino)benzenesulfonamide
Code : 2W05
Header : TRANSFERASE
Title : Structure of CDK2 in complex with an imidazolyl pyrimidine, compound 5b
Release Data : 2008-10-14
Compound :
mol_id molecule chains synonym
1 CELL DIVISION PROTEIN KINASE 2 A P33 PROTEIN KINASE, CDK2
ec: 2.7.11.22
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_cell_line: Sf21
expression_system_vector_type: BACULOVIRUS
Authors : Anderson, M., Andrews, D.M., Barker, A.J., Brassington, C.A., Breed, J., Byth, K.F., Culshaw, J.D., Finlay, M.R., Fisher, E., Green, C.P., Heaton, D.W., Nash, I.A., Newcombe, N.J., Oakes, S.E., Pauptit, R.A., Roberts, A., Stanway, J.J., Thomas, A.P., Tucker, J.A., Weir, H.M.
Keywords : KINASE, MITOSIS, CELL CYCLE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, POLYMORPHISM, CELL DIVISION, PHOSPHOPROTEIN, PHOSPHORYLATION, NUCLEOTIDE-BINDING
Exp. method : X-RAY DIFFRACTION ( 1.9 Å )
Citation :

Imidazoles: Sar and Development of a Potent Class of Cyclin-Dependent Kinase Inhibitors.

Anderson, M.,Andrews, D.M.,Barker, A.J.  et al.
(2008)  Bioorg.Med.Chem.Lett.  18 : 5487

PubMed: 18815031
DOI: 10.1016/J.BMCL.2008.09.024

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.