Brand  (β version)

PDB ID: 2VZ6

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Ligands
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FEF (2z,3e)-2,3'-biindole-2',3(1h,1'H)-dione 3-{O-[(3r)-3,4-dihydroxybutyl]oxime} PoSSuM
PGO S-1,2-propanediol PoSSuM
Non-standard Residues
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Structure summary

Code : 2VZ6   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in complex with Indirubin E804
Release Data : 2008-08-26
Compound :
mol_id molecule chains synonym
1 CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN A,B CAM-KINASE II ALPHA CHAIN, CAM KINASE II SUBUNIT ALPHA, CAMK-II SUBUNIT ALPHA
ec: 2.7.11.17
fragment: KINASE DOMAIN, RESIDUES 13-302
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_variant: R3-PRARE2
expression_system_plasmid: PNIC28-BSA4
Authors : Pike, A.C.W., Rellos, P., King, O., Salah, E., Parizotto, E., Fedorov, O., Shrestha, L., Burgess-Brown, N., Roos, A., Murray, J.W., von Delft, F., Edwards, A., Arrowsmith, C.H., Wikstroem, M., Bountra, C., Knapp, S.
Keywords : TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, CELL JUNCTION, CELL MEMBRANE, LONG TERM POTENTIATION, BRAIN, KINASE, SYNAPSE, MEMBRANE, NMDA RECEPTOR SIGNALLING, PHOSPHOPROTEIN, CALMODULIN-BINDING, NUCLEOTIDE-BINDING
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation.

Rellos, P.,Pike, A.C.W.,Niesen, F.H.  et al.
(2010)  Plos Biol.  8 : 426

PubMed: 20668654
DOI: 10.1371/JOURNAL.PBIO.1000426

Reaction

Chain : A, B
UniProt : Q9UQM7 (KCC2A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.17 PubMed:23805378
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.17 PubMed:23805378
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