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Ligands
Code Name Style Show Link
ANP Phosphoaminophosphonic acid-adenylate ester
AU Gold ion
MG Magnesium ion
Non-standard Residues
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Glycosylation
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Code : 2VWI   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure of the OSR1 kinase, a hypertension drug target
Release Data : 2008-07-08
Compound :
mol_id molecule chains synonym
1 SERINE/THREONINE-PROTEIN KINASE OSR1 A,B,C,D OXIDATIVE STRESS- RESPONSIVE 1 PROTEIN, OSR1
ec: 2.7.11.1
fragment: KINASE DOMAIN, RESIDUES 1-303
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:511693)
expression_system_strain: BL21
Authors : Villa, F., Deak, M., Alessi, D.R., vanAalten, D.M.F.
Keywords : KINASE, STE KINASE, HYPERTENSION, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

Structure of the Osr1 Kinase, a Hypertension Drug Target.

Villa, F.,Deak, M.,Alessi, D.R.  et al.
(2008)  Proteins  73 : 1082

PubMed: 18831043
DOI: 10.1002/PROT.22238

Chain : A, B, C, D
UniProt : O95747 (OXSR1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:14707132, PubMed:21321328
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:14707132, PubMed:16669787, PubMed:18270262, PubMed:21321328
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