Brand  (β version)

PDB ID: 2VSR

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Ligands
Code Name Style Show Link
9HO (9s,10e,12z)-9-hydroxyoctadeca-10,12-dienoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 2VSR   PDBj   RCSB PDB   PDBe
Header : RECEPTOR
Title : hPPARgamma Ligand binding domain in complex with 9-(S)-HODE
Release Data : 2008-08-19
Compound :
mol_id molecule chains synonym
1 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA A,B PPAR GAMMA, NUCLEAR RECEPTOR SUBFAMILY 1 GROUP C MEMBER 3
fragment: LIGAND BINDING DOMAIN, RESIDUES 202-475
other_details: 9-(S)-HODE
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:511693)
expression_system_strain: BL21
expression_system_variant: ROSETTA
expression_system_plasmid: PET30A MODIFIED
Authors : Itoh, T., Fairall, L., Schwabe, J.W.R.
Keywords : TRANSCRIPTION REGULATION, ALTERNATIVE SPLICING, LIGAND BINDING DOMAIN, NUCLEAR RECEPTOR, DIABETES MELLITUS, ZINC-FINGER, DNA-BINDING, POLYMORPHISM, TRANSCRIPTION, ZINC, OBESITY, NUCLEUS, RECEPTOR, ACTIVATOR, OXIDISED FATTY ACID, TRANSCRIPTION FACTOR, METAL-BINDING, PHOSPHOPROTEIN, DISEASE MUTATION
Exp. method : X-RAY DIFFRACTION ( 2.05 Å )
Citation :

Structural Basis for the Activation of Pparg by Oxidised Fatty Acids

Itoh, T.,Fairall, L.,Amin, K.  et al.
(2008)  Nat.Struct.Mol.Biol.  15 : 924

PubMed: 19172745
DOI: 10.1038/NSMB.1474

Reaction

Chain : A, B
UniProt : P37231 (PPARG_HUMAN)
Reaction : -