Het-PDB Navi2 (PDB: 2VMY)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name	Link
FFO	N-[4-({[(6s)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid	PoSSuM
GLY	Glycine	PoSSuM
MRD	(4r)-2-methylpentane-2,4-diol	PoSSuM
PLP	Pyridoxal-5'-phosphate	PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 2VMY

Code :

2VMY PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of F351GbsSHMT in complex with Gly and FTHF

Release Data :

2008-12-16

Compound :

mol_id	molecule	chains	synonym
1	SERINE HYDROXYMETHYLTRANSFERASE	A,B	SHMT, SERINE METHYLASE
	ec: 2.1.2.1 fragment: RESIDUES 1-405 mutation: YES

Source :

mol_id	organism_scientific	expression_system
1	BACILLUS STEAROTHERMOPHILUS (taxid:1422)	ESCHERICHIA COLI (taxid:511693)
	expression_system_strain: BL21 expression_system_vector_type: PLASMID expression_system_vector: PRSET C

Authors :

Rajaram, V., Pai, V.R., Bisht, S., Bhavani, B.S., Appaji Rao, N., Savithri, H.S., Murthy, M.R.N.

Keywords :

TRANSFERASE, ONE-CARBON METABOLISM, PLP-DEPENDENT ENZYMES, SERINE TERNARY COMPLEX, PYRIDOXAL PHOSPHATE, F351G, FOLATE BINDING

Exp. method :

X-RAY DIFFRACTION ( 2.70 Å )

Citation :

Structural and Functional Studies of Bacillus Stearothermophilus Serine Hydroxymethyltransferase: The Role of Asn(341), Tyr(60) and Phe(351) in Tetrahydrofolate Binding.

Pai, V.R.,Rajaram, V.,Bisht, S. et al.
(2009) Biochem.J. 418 : 635

PubMed: 19046138
DOI: 10.1042/BJ20081739

Chain :

A, B

UniProt :

Q7SIB6 (Q7SIB6_GEOSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine	2.1.2.1	ARBA:ARBA00001528, HAMAP-Rule:MF_00051
	-	ARBA:ARBA00001528, HAMAP-Rule:MF_00051
Cofactor:	Evidence:	Note:
pyridoxal 5'-phosphate	ECO:0000256 \| ARBA:ARBA00001933 ECO:0000256 \| HAMAP-Rule:MF_00051 ECO:0000256 \| PIRSR:PIRSR000412-50	-

PDB ID: 2VMY

Hetero Atom Contents

Structure summary

Reaction