Brand  (β version)

PDB ID: 2V61

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Ligands
Code Name Style Show Link
C18 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2h-chromen-2-one PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
Non-standard Residues
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Structure summary

Code : 2V61   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Structure of human MAO B in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-(methylamino)methyl-coumarin
Release Data : 2007-10-16
Compound :
mol_id molecule chains synonym
1 AMINE OXIDASE (FLAVIN-CONTAINING) B A,B MONOAMINE OXIDASE TYPE B, MAO-B, MONOAMINE OXIDASE
ec: 1.4.3.4
Source :
mol_id organism_scientific expression_system
1 HOMO SAPIENS  (taxid:9606) PICHIA PASTORIS  (taxid:4922)
Authors : Binda, C., Wang, J., Pisani, L., Caccia, C., Carotti, A., Salvati, P., Edmondson, D.E., Mattevi, A.
Keywords : FAD, MEMBRANE, SAFINAMIDE, FLAVOPROTEIN, HUMAN MAO B STRUCTURE, REVERSIBLE INHIBITOR BINDING, MITOCHONDRION, TRANSMEMBRANE, OXIDOREDUCTASE, NEUROPROTECTION, PARKINSON'S DISEASE
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs.

Binda, C.,Wang, J.,Pisani, L.  et al.
(2007)  J.Med.Chem.  50 : 5848

PubMed: 17915852
DOI: 10.1021/JM070677Y

Reaction

Chain : A, B
UniProt : P27338 (AOFB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a secondary aliphatic amine + H2O + O2 = a primary amine + an aldehyde + H2O2 1.4.3.4 PubMed:20493079
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(R)-adrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine - PubMed:20493079
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an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+) 1.4.3.21 PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924
left-to-right PubMed:11049757
benzylamine + H2O + O2 = benzaldehyde + H2O2 + NH4(+) - PubMed:11049757
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dopamine + H2O + O2 = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+) - PubMed:20493079
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H2O + O2 + tyramine = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+) - PubMed:20493079
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(R)-noradrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+) - PubMed:20493079
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2-phenylethylamine + H2O + O2 = 2-phenylacetaldehyde + H2O2 + NH4(+) - PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924
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H2O + N-acetylputrescine + O2 = 4-acetamidobutanal + H2O2 + NH4(+) - UniProtKB:P19643
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