Brand  (β version)

PDB ID: 2V35

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
J54 (2r)-3-{[(benzylamino)carbonyl]amino}-2-hydroxypropanoic acid PoSSuM
NA Sodium ion PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 2V35   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Porcine Pancreatic Elastase in complex with inhibitor JM54
Release Data : 2008-06-24
Compound :
mol_id molecule chains synonym
1 ELASTASE-1 A PORCINE PANCREATIC ELASTASE
ec: 3.4.21.36
Source :
mol_id organism_scientific organism_common
1 SUS SCROFA  (taxid:9823) PIG
organ: PANCREAS
Authors : Oliveira, T.F., Mulchande, J., Martins, L., Moreira, R., Iley, J., Archer, M.
Keywords : SERINE PROTEASE, SERINE PROTEASES, CALCIUM, ZYMOGEN, PROTEASE, ELASTASE, HYDROLASE, INHIBITION, BETA-LACTAMS, METAL-BINDING
Exp. method : X-RAY DIFFRACTION ( 1.67 Å )
Citation :

The Efficiency of C-4 Substituents in Activating the Beta-Lactam Scaffold Towards Serine Proteases and Hydroxide Ion.

Mulchande, J.,Martins, L.,Moreira, R.  et al.
(2007)  Org.Biomol.Chem.  5 : 2617

PubMed: 18019537
DOI: 10.1039/B706622H

Crystallization and Preliminary Diffraction Studies of Porcine Pancreatic Elastase in Complex with a Novel Inhibitor

Oliveira, T.F.,Mulchande, J.,Moreira, R.  et al.
(2007)  Protein Pept.Lett.  14 : 93

PubMed: 17266656
DOI: 10.2174/092986607779117173

Reaction

Chain : A
UniProt : P00772 (CELA1_PIG)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa. 3.4.21.36 PubMed:5415108
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