Brand  (β version)

PDB ID: 2V11

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Ligands
Code Name Style Show Link
C80 (2s,4s,5r,7r)-4-amino-8-(butylamino)-5-hydroxy-2,7-dimethyl-8-oxooctyl 1-benzyl-1h-indole-3-carboxylate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2V11   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of Renin with Inhibitor 6
Release Data : 2007-07-03
Compound :
mol_id molecule chains synonym
1 RENIN C,O ANGIOTENSINOGENASE
ec: 3.4.23.15
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN CRICETULUS GRISEUS  (taxid:10029)
expression_system_cell_line: CHO
Authors : Rahuel, J., Rasetti, V., Maibaum, J., Rueger, H., Goschke, R., Cohen, N.C., Stutz, S., Cumin, F., Fuhrer, W., Wood, J.M., Grutter, M.G.
Keywords : GLYCOPROTEIN, INHIBITOR-COMPLEX, ASPARTYL PROTEASE, ZYMOGEN, PROTEASE, HYDROLASE, POLYMORPHISM, ALTERNATIVE SPLICING, HYDROLASE(ACID PROTEINASE), CLEAVAGE ON PAIR OF BASIC RESIDUES
Exp. method : X-RAY DIFFRACTION ( 3.1 Å )
Citation :

Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin

Rahuel, J.,Rasetti, V.,Maibaum, J.  et al.
(2000)  Chem.Biol.  7 : 493

PubMed: 10903938
DOI: 10.1016/S1074-5521(00)00134-4

The Crystal Structures of Recombinant Glycosylated Human Renin Alone and in Complex with a Transition State Analog Inhibitor.

Rahuel, J.,Priestle, J.P.,Grutter, M.G.
(1991)  J.Struct.Biol.  107 : 227

PubMed: 1807356
DOI: 10.1016/1047-8477(91)90048-2

Reaction

Chain : C, O
UniProt : P00797 (RENI_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I. 3.4.23.15 PubMed:12045255, PubMed:20927107
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