PDB ID: 2UZL
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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C94 | 4-{5-[(z)-(2-imino-4-oxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl}-2-(trifluoromethyl)benzenesulfonamide | PoSSuM |
Code | Name | Show |
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TPO | Phosphothreonine |
Code | Name | Emphasize |
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Download interaction data: 2UZL
Structure summary
Code : | 2UZL PDBj RCSB PDB PDBe | ||||||||||||||||||||||||
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Header : | TRANSFERASE | ||||||||||||||||||||||||
Title : | Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor | ||||||||||||||||||||||||
Release Data : | 2007-06-26 | ||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Richardson, C.M., Dokurno, P., Murray, J.B., Surgenor, A.E. | ||||||||||||||||||||||||
Keywords : | TRANSFERASE, ATP-BINDING, PHOSPHORYLATION, CDK2, KINASE, CYCLIN, MITOSIS, CELL CYCLE, CELL DIVISION, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, THIAZOLIDINONE LIGAND | ||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.40 Å ) | ||||||||||||||||||||||||
Citation : |
Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping.
Richardson, C.M.,Nunns, C.L.,Williamson, D.S.
et al.
PubMed: 17570665 |
Reaction
Chain : | A, C | ||||||||||||
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UniProt : | P24941 (CDK2_HUMAN) | ||||||||||||
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Chain : | B, D |
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UniProt : | P20248 (CCNA2_HUMAN) |
Reaction : | - |