Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
C85 4-{5-[(z)-(2-imino-4-oxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl}benzenesulfonamide
Modified Residues
Code Name Link
TPO Phosphothreonine
Code : 2UZD
Header : TRANSFERASE
Title : Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
Release Data : 2007-06-26
Compound :
mol_id molecule chains synonym
1 CELL DIVISION PROTEIN KINASE 2 A,C P33 PROTEIN KINASE, CYCLIN DEPENDENT KINASE 2
ec: 2.7.11.22, 2.7.1.37
other_details: THR160 PHOSPHORYLATED
mol_id molecule chains synonym
2 CYCLIN A2 B,D CYCLIN-A
fragment: 175-432
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:511693)
expression_system_strain: BL21
expression_system_vector: PGEX
mol_id organism_scientific organism_common expression_system
2 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:511693)
expression_system_strain: BL21
expression_system_vector: PET41A
Authors : Richardson, C.M., Dokurno, P., Murray, J.B., Surgenor, A.E.
Keywords : TRANSFERASE, ATP-BINDING, PHOSPHORYLATION, CDK2, KINASE, CYCLIN, MITOSIS, CELL CYCLE, CELL DIVISION, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, THIAZOLIDINONE LIGAND
Exp. method : X-RAY DIFFRACTION ( 2.72 Å )
Citation :

Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping.

Richardson, C.M.,Nunns, C.L.,Williamson, D.S.  et al.
(2007)  Bioorg.Med.Chem.Lett.  17 : 3880

PubMed: 17570665
DOI: 10.1016/J.BMCL.2007.04.110

Chain : A, C
UniProt : P24941 (CDK2_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.
Chain : B, D
UniProt : P20248 (CCNA2_HUMAN)
Reaction : -