Brand  (β version)

PDB ID: 2UXX

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
FAJ Fad-trans-2-phenylcyclopropylamine adduct PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 2UXX   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/REPRESSOR
Title : Human LSD1 Histone Demethylase-CoREST in complex with an FAD- tranylcypromine adduct
Release Data : 2007-08-21
Compound :
mol_id molecule chains synonym
1 LYSINE-SPECIFIC HISTONE DEMETHYLASE 1 A FLAVIN-CONTAINING AMINE OXIDASE DOMAIN-CONTAINING PROTEIN 2, BRAF35-HDAC COMPLEX PROTEIN BHC110, LYSINE- SPECIFIC DEMETHYLASE 1
ec: 1.-.-.-
fragment: SWIRM DOMAIN, AMINE OXIDASE DOMAIN AND LINKER, RESIDUES 171-836
mol_id molecule chains synonym
2 REST COREPRESSOR 1 B PROTEIN COREST, NUCLEAR RECEPTOR COREPRESSOR 2
fragment: FRAGMENT OF SANT1, LINKER REGION AND SANT2 DOMAIN, RESIDUES 308-482
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:511693)
expression_system_strain: BL21
expression_system_vector: PGEX-6P1
expression_system_plasmid: MJ23
mol_id organism_scientific organism_common expression_system
2 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:511693)
expression_system_strain: BL21
expression_system_vector: PET-28
expression_system_plasmid: MJ65
Authors : Yang, M., Culhane, J.C., Machius, M., Cole, P.A., Yu, H.
Keywords : OXIDOREDUCTASE-REPRESSOR COMPLEX, HISTONE DEMETHYLASE, OXIDOREDUCTASE, NUCLEAR PROTEIN, PHOSPHORYLATION, TRANSCRIPTION REGULATION, TRANYLCYPROMINE, CHROMATIN REGULATOR, NUCLEOSOMES, TRANSCRIPTION, HOST-VIRUS INTERACTION, CHROMATIN DEMETHYLATION, FAD, LSD1, COREST, REPRESSOR, DEPRESSION
Exp. method : X-RAY DIFFRACTION ( 2.74 Å )
Citation :

Structural Basis for the Inhibition of the Lsd1 Histone Demethylase by the Antidepressant Trans-2-Phenylcyclopropylamine.

Yang, M.,Culhane, J.C.,Szewczuk, L.M.  et al.
(2007)  Biochemistry  46 : 8058

PubMed: 17569509
DOI: 10.1021/BI700664Y

Structural Basis for Corest-Dependent Demethylation of Nucleosomes by the Human Lsd1 Histone Demethylase

Yang, M.,Gocke, C.B.,Luo, X.  et al.
(2006)  Molecular Cell  23 : 377

PubMed: 16885027
DOI: 10.1016/J.MOLCEL.2006.07.012

Reaction

Chain : A
UniProt : O60341 (KDM1A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3] 1.14.99.66 PubMed:15620353, PubMed:15811342
-
Chain : B
UniProt : Q9UKL0 (RCOR1_HUMAN)
Reaction : -