Het-PDB Navi2 (PDB: 2UXX)

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Ligands
Code	Name	Link
CL	Chloride ion	PoSSuM
FAJ	Fad-trans-2-phenylcyclopropylamine adduct	PoSSuM
GOL	Glycerol	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2UXX

Code :

2UXX PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE/REPRESSOR

Title :

Human LSD1 Histone Demethylase-CoREST in complex with an FAD- tranylcypromine adduct

Release Data :

2007-08-21

Compound :

mol_id	molecule	chains	synonym
1	LYSINE-SPECIFIC HISTONE DEMETHYLASE 1	A	FLAVIN-CONTAINING AMINE OXIDASE DOMAIN-CONTAINING PROTEIN 2, BRAF35-HDAC COMPLEX PROTEIN BHC110, LYSINE- SPECIFIC DEMETHYLASE 1
	ec: 1.-.-.- fragment: SWIRM DOMAIN, AMINE OXIDASE DOMAIN AND LINKER, RESIDUES 171-836

mol_id	molecule	chains	synonym
2	REST COREPRESSOR 1	B	PROTEIN COREST, NUCLEAR RECEPTOR COREPRESSOR 2
	fragment: FRAGMENT OF SANT1, LINKER REGION AND SANT2 DOMAIN, RESIDUES 308-482

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:511693)
	expression_system_strain: BL21 expression_system_vector: PGEX-6P1 expression_system_plasmid: MJ23

mol_id	organism_scientific	organism_common	expression_system
2	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:511693)
	expression_system_strain: BL21 expression_system_vector: PET-28 expression_system_plasmid: MJ65

Authors :

Yang, M., Culhane, J.C., Machius, M., Cole, P.A., Yu, H.

Keywords :

OXIDOREDUCTASE-REPRESSOR COMPLEX, HISTONE DEMETHYLASE, OXIDOREDUCTASE, NUCLEAR PROTEIN, PHOSPHORYLATION, TRANSCRIPTION REGULATION, TRANYLCYPROMINE, CHROMATIN REGULATOR, NUCLEOSOMES, TRANSCRIPTION, HOST-VIRUS INTERACTION, CHROMATIN DEMETHYLATION, FAD, LSD1, COREST, REPRESSOR, DEPRESSION

Exp. method :

X-RAY DIFFRACTION ( 2.74 Å )

Citation :

Structural Basis for the Inhibition of the Lsd1 Histone Demethylase by the Antidepressant Trans-2-Phenylcyclopropylamine.

Yang, M.,Culhane, J.C.,Szewczuk, L.M. et al.
(2007) Biochemistry 46 : 8058

PubMed: 17569509
DOI: 10.1021/BI700664Y

Structural Basis for Corest-Dependent Demethylation of Nucleosomes by the Human Lsd1 Histone Demethylase

Yang, M.,Gocke, C.B.,Luo, X. et al.
(2006) Molecular Cell 23 : 377

PubMed: 16885027
DOI: 10.1016/J.MOLCEL.2006.07.012

Chain :

UniProt :

O60341 (KDM1A_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L- lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2	1.14.99.66	PubMed:15620353, PubMed:15811342, PubMed:27292636
	-	PubMed:15620353, PubMed:15811342, PubMed:27292636
Cofactor:	Evidence:	Note:
FAD	ECO:0000269 \| PubMed:15620353 ECO:0000269 \| PubMed:15811342 ECO:0000269 \| PubMed:16956976 ECO:0000269 \| PubMed:21300290 ECO:0000269 \| PubMed:23721412	-

Chain :	B
UniProt :	Q9UKL0 (RCOR1_HUMAN)
Reaction :	-

PDB ID: 2UXX

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