Brand  (β version)

PDB ID: 2R7N

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Ligands
Code Name Style Show Link
ADP Adenosine-5'-diphosphate PoSSuM
CL Chloride ion PoSSuM
FAI 5-(formylamino)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1h-imidazole-4-carboxamide PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2R7N   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ADP and FAICAR
Release Data : 2007-12-04
Compound :
mol_id molecule chains synonym
1 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase A 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate-formate ligase
ec: 6.3.4.-
Source :
mol_id organism_scientific expression_system
1 Methanocaldococcus jannaschii  (taxid:2190) Escherichia coli  (taxid:562)
gene: purP
expression_system_cell_line: B834(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET19
Authors : Zhang, Y., White, R.H., Ealick, S.E.
Keywords : ATP-grasp superfamily, ATP-binding, Ligase, Magnesium, Manganese, Metal-binding, Nucleotide-binding
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.

Zhang, Y.,White, R.H.,Ealick, S.E.
(2008)  Biochemistry  47 : 205 - 217

PubMed: 18069798
DOI: 10.1021/bi701406g

Reaction

Chain : A
UniProt : Q57600 (PURP_METJA)
Reaction: EC: Evidence:
Physiological Direction:
5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + formate + ATP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide + ADP + phosphate 6.3.4.23 HAMAP-Rule:MF_01163
-
Cofactor: Evidence: Note:
Mn(2+) ECO:0000269 | PubMed:15623504
ECO:0000269 | PubMed:15623504
Binds 1 Mg(2+) or Mn(2+) ion per subunit.