Brand  (β version)

PDB ID: 2R3Q

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Ligands
Code Name Style Show Link
5SC 3-((3-bromo-5-O-tolylpyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide PoSSuM
Non-standard Residues
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CSD 3-sulfinoalanine
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ACE Acetyl group

Structure summary

Code : 2R3Q   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor
Release Data : 2008-01-22
Compound :
mol_id molecule chains synonym
1 Cell division protein kinase 2 A p33 protein kinase
ec: 2.7.11.22
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Unidentified baculovirus  (taxid:10469)
gene: CDK2
expression_system_strain: SF9
Authors : Fischmann, T.O., Hruza, A.W., Madison, V.M., Duca, J.S.
Keywords : SERINE/THREONINE-PROTEIN KINASE, CELL CYCLE, INHIBITION, CYCLIN-DEPENDENT KINASE, CANCER, ATP-binding, Cell division, Mitosis, Nucleotide-binding, Phosphorylation, Polymorphism, Transferase
Exp. method : X-RAY DIFFRACTION ( 1.35 Å )
Citation :

Structure-guided discovery of cyclin-dependent kinase inhibitors.

Fischmann, T.O.,Hruza, A.,Duca, J.S.  et al.
(2008)  Biopolymers  89 : 372 - 379

PubMed: 17937404
DOI: 10.1002/bip.20868

Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors.

Dwyer, M.P.,Paruch, K.,Alvarez, C.  et al.
(2007)  Bioorg.Med.Chem.Lett.  17 : 6216 - 6219

PubMed: 17904366
DOI: 10.1016/j.bmcl.2007.09.018

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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